held mine ages
#retatrutide 2025-04-14
Monday38 messages8 participantstimes are UTC
Highlights from this day
- blank_run — always. means hide the tails and the tails are the people who need to pay attention 21:52
- mg_per_ml — back — also caffeine. two people posted alarming HR jumps last year and both had doubled their coffee because food had stopped being interesting 22:56
- the_bet_2026 — guilty. that was probably 3 of my 13 23:27
- mg_per_ml — the most honest sentence in the archive 23:58
follow up how do people square the research use only framing with logging their own use
the honest position is this has less human evidence behind it than anything else discussed here
whats the half life like, is it weekly the same way
reconstituted the 30 vial to 2mg/ml specifically so i could take 1 without measuring crumbs
logging rhr daily
the honest position is this has less human evidence behind it than anything else discussed here
anyone compared their VendorInvestigate purity across two different KP lots
❤️5
stopped for 3 months and restarted at half my old dose, the ramp was easier second time
everyone warns about the heart rate. how much are we talking
in the phase 2 the mean increase was a few beats per minute, largest around the middle of the trial and smaller by week 48
so it went up and then partly came back while people stayed on drug
why up at all
glucagon receptor agonism raises heart rate. it is not a mystery finding, it is expected from the mechanism
GLP-1 agonists also nudge it up a little on their own, so you are stacking two small effects
mine went from resting 58 to resting 71 over about ten weeks and that got my attention fast
thirteen beats is not a few
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no it isnt. thats why i held the dose for two months instead of climbing
and the mean hides exactly that. a mean of four means somebody got twelve
always. means hide the tails and the tails are the people who need to pay attention
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did yours come back
to 63 after four months at the same dose. never back to 58
worth saying: a persistent double digit resting HR rise is a talk to a doctor thing, not a chat thing
i did. thats partly why i held
how are people even measuring resting HR properly
first thing on waking, before sitting up, three days in a row, same device
a watch overnight average is fine for trend but the absolute number will differ from a cuff
does BP move too
the GLP-1 side tends to lower systolic a bit. glucagon pushing HR up while BP drifts down is a fairly common pattern in the logs here
thats exactly what mine did, systolic came down 8 or 9 and HR went up
that is a weird combination
physiologically its coherent. different mechanisms, different directions
one sec
back — also caffeine. two people posted alarming HR jumps last year and both had doubled their coffee because food had stopped being interesting
guilty. that was probably 3 of my 13
😂12☕6
your 58 to 71 — was that during escalation or after you settled
during. it climbed with the dose and then partly settled once i stopped climbing, which is what @blank_run said would happen
i said what the trial mean did. yours doing the same thing is a coincidence i will happily take credit for
the most honest sentence in the archive
😄7