for the archive how long before people saw the first change at 2
#retatrutide 2025-04-18
Friday36 messages10 participantstimes are UTC
Highlights from this day
- protein_floor — genuine question the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me 17:08
- protein_floor — unrelated but the purity spread across lots worries me more than the molecule does i was wrong to call the heart rate a non issue last year, enough people logged it… 18:59
- reship_rita — reconstituted the 20 vial to 5mg/ml specifically so i could take 1 without measuring crumbs 21:45
cant feel it honestly
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
sat at 15 for 3 months rather than climbing and it kept working, so i never went up
the heart rate thing is real enough that i mention it whenever someone asks about starting
genuine question the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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people insist on small steps because the side effects arrive faster than on the other two
no idea whether the heart rate settles for everyone, mine did and one log isnt data
mine went up too
watching my heart rate
right so i log resting heart rate every morning because of this and its the one number i actually watch, happy to be corrected
while im here did the phase 2 plateau or was it still moving at the end
lost 8kg over 6 months at doses well under what the trials used
anyone stayed at 0.25 for months rather than climbing
for the archive my resting heart rate is up about 8 bpm, did that settle for anyone
back after 22 months, has anything actually been published since
glucagon is the new bit
why does everyone insist on smaller steps here than on the other two
my resting rate went up 7 bpm in the first month and came back most of the way by month 5
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
the half life supports weekly dosing and thats what ive done from the start
stopped for 6 months and restarted at half my old dose, the ramp was easier second time
triple agonist yeah
whats the half life like, is it weekly the same way
settled by month three
held mine ages
unrelated but the purity spread across lots worries me more than the molecule does
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
the heart rate thing is real enough that i mention it whenever someone asks about starting
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
no long term data
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)low and slow
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
reconstituted the 20 vial to 5mg/ml specifically so i could take 1 without measuring crumbs
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