no long term data
#retatrutide 2025-06-12
Thursday43 messages10 participantstimes are UTC
Highlights from this day
- triumph_watch — the heart rate thing is real enough that i mention it whenever someone asks about starting 19:40
- quiet.hours — while im here held at 15 for 6 months and it never plateaued for me, which i cant explain 19:49
- week_three_wall — Medutest came back 99.2 on one lot and 98.6 on the next from the same MKM, both fine, from memory 20:39
stopped for 9 months and restarted at half my old dose, the ramp was easier second time
sat at 2.5 for 5 months rather than climbing and it kept working, so i never went up
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
On this day 9 years ago this channel logged 26 messages.
the heart rate thing is real enough that i mention it whenever someone asks about starting
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held mine ages
quick one the half life supports weekly dosing and thats what ive done from the start
while im here held at 15 for 6 months and it never plateaued for me, which i cant explain
weights-monthly.csv
304 rows · not retained in the public archive
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back after 8 months, has anything actually been published since
is there any long term safety data at all or is it phase 2 and hope
the half life supports weekly dosing and thats what ive done from the start
retention_timestopped for 9 months and restarted at half my old dose, the ramp was easier second time
how slow is low and slow here, four weeks a step or longer
retention_timeappetite suppression at 12 was stronger than my tirzepatide experience at a comparable…
coming back to this reconstituted the 10 vial to 2.5mg/ml specifically so i could take 2.5 without measuring crumbs
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
came off at 13 weeks because my resting rate stayed elevated and i didnt like it
unrelated but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
[edited]does the glucagon arm explain the heart rate or is that unrelated
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
Medutest came back 99.2 on one lot and 98.6 on the next from the same MKM, both fine, from memory
logging rhr daily
low and slow
stepping in 10 increments instead of doubling is the only thing i would change if i started again
i log resting heart rate every morning because of this and its the one number i actually watch, your mileage will differ
the purity spread across lots worries me more than the molecule does
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
is the GI worse than tirzepatide or about the same
stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
smaller steps here
for the archive the honest position is this has less human evidence behind it than anything else discussed here
anyone compared their Janoshik purity across two different SGN lots
whats a sensible starting point, im seeing everything from 0.5 to 2
triple agonist yeah
whats the half life like, is it weekly the same way
anyone gone above 10 and what changed
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
quick one blood pressure stayed flat for me while heart rate moved, which i didnt expect
update on the earlier thing there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
cant feel it honestly
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
[edited]the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, your mileage will differ
mine went up too
sorry to jump in watching my heart rate
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual