triple agonist yeah
#retatrutide 2025-07-13
Sunday38 messages10 participantstimes are UTC
Highlights from this day
VendorInvestigate came back 98.6 on one lot and 99.4 on the next from the same CPC, both fine
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settled by month three
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
held mine ages
lost 23kg over 13 months at doses well under what the trials used
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, i have it written down somewhere
phase 2 only
how slow is low and slow here, four weeks a step or longer
watching my heart rate
while im here is the GI worse than tirzepatide or about the same
how do people square the research use only framing with logging their own use
nobody should read my log as a plan, im recording what i did and thats all it is
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did anyone come off because of the heart rate
right so whats a sensible starting point, im seeing everything from 0.5 to 2
smaller steps here
Verification log updated: CPC — evidence added, status unchanged.
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
mine went up too
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ill dig out the number
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research use only
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low and slow
quick one there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
sorry to jump in i log resting heart rate every morning because of this and its the one number i actually watch
does the glucagon arm explain the heart rate or is that unrelated
held at 1.7 for 17 months and it never plateaued for me, which i cant explain
right so triple agonist meaning GLP-1, GIP and glucagon, have i got that right
GI was about the same as tirzepatide for me, the difference was how fast it arrived
no idea whether the heart rate settles for everyone, mine did and one log isnt data
the honest position is this has less human evidence behind it than anything else discussed here
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Purity check: no report on file for lot C-4402. Nothing logged either way.
anyone logging resting heart rate on this
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unrelated but is the glucagon arm what people mean by the energy expenditure thing
no long term data
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point
anyone stayed at 15 for months rather than climbing
did the phase 2 result actually come in higher than the tirzepatide numbers
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