the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
i said 9 months ago that my heart rate had settled and it has stayed settled since
#retatrutide 2025-07-16
Wednesday26 messages6 participantstimes are UTC
Highlights from this day
- see_a_clinician — the honest position is this has less human evidence behind it than anything else discussed here 23:10
- homa_ir_hugo — PeptideMeter came back 98.6 on one lot and 97.4 on the next from the same KP, both fine 23:16
- ema_vs_national — did the phase 2 result actually come in higher than the tirzepatide numbers 23:55
glucagon is the new bit
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
TRIUMPH is phase 3
slightly off topic but i log resting heart rate every morning because of this and its the one number i actually watch
the honest position is this has less human evidence behind it than anything else discussed here
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quick one came off at 13 weeks because my resting rate stayed elevated and i didnt like it
[edited]held mine ages
PeptideMeter came back 98.6 on one lot and 97.4 on the next from the same KP, both fine
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coming back to this i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
the purity spread across lots worries me more than the molecule does, your mileage will differ
does the energy expenditure claim show up as anything you can feel
people insist on small steps because the side effects arrive faster than on the other two
anyone compared their VendorInvestigate purity across two different BCH lots
cant feel it honestly
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the heart rate thing is real enough that i mention it whenever someone asks about starting
settled by month three
how slow is low and slow here, four weeks a step or longer
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
lost 5kg over 26 months at doses well under what the trials used
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
stepping in 0.5 increments instead of doubling is the only thing i would change if i started again, someone check my working
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low and slow
research use only
mine went up too
did the phase 2 result actually come in higher than the tirzepatide numbers
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