how long before people saw the first change at 1.7
#retatrutide 2025-08-13
Wednesday37 messages11 participantstimes are UTC
Highlights from this day
- u100_pat — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 11:20
- hr_log_hattie — sat at 12 for 8 months rather than climbing and it kept working, so i never went up 11:51
- half_life_hal — whats a sensible starting point, im seeing everything from 0.5 to 2 12:51
research use only
glucagon is the new bit
my resting rate went up 6 bpm in the first month and came back most of the way by month 25
anyone compared their PeptideMeter purity across two different GGPeps lots
mine went up too
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the purity spread across lots worries me more than the molecule does
whats the half life like, is it weekly the same way
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
[edited]TRIUMPH is phase 3
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no long term data
why does everyone insist on smaller steps here than on the other two
phase 2 only
my resting heart rate is up about 3 bpm, did that settle for anyone
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no idea whether the heart rate settles for everyone, mine did and one log isnt data
slightly off topic but GI was about the same as tirzepatide for me, the difference was how fast it arrived
genuine question came off at 4 weeks because my resting rate stayed elevated and i didnt like it
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
held mine ages
Inter-lab diff for lot G-0641: 96.8% vs 99%. Within expected range.
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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the honest position is this has less human evidence behind it than anything else discussed here
lot-log.csv
840 rows · not retained in the public archive
does the glucagon arm explain the heart rate or is that unrelated
PeptideMeter came back 99.4 on one lot and 99 on the next from the same MKM, both fine
does the energy expenditure claim show up as anything you can feel
sat at 12 for 8 months rather than climbing and it kept working, so i never went up
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cant feel it honestly
whats a sensible starting point, im seeing everything from 0.5 to 2
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low and slow
smaller steps here
update on the earlier thing research use only is on every vial and i treat it as exactly that, nobody here is prescribing
triple agonist yeah
stepping in 1 increments instead of doubling is the only thing i would change if i started again
is the phase 2 dosing anywhere near what people here run
Archive lookup: first_and_last_four first appears in this channel on 2025-04-23.
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial