vialroom

#retatrutide 2025-08-29

Friday44 messages10 participantstimes are UTC
Highlights from this day
  • comment_fatigue — why does everyone insist on smaller steps here than on the other two 18:18
  • patent_2026 — Janoshik came back 96.8 on one lot and 98.1 on the next from the same WXT, both fine 19:26
  • patent_2026 — follow up GI was about the same as tirzepatide for me, the difference was how fast it arrived 19:27
CF

nobody should read my log as a plan, im recording what i did and thats all it is

is the glucagon arm what people mean by the energy expenditure thing

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CF

logging rhr daily

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
MO

follow up anyone compared their Medutest purity across two different JEEP lots

CF

the purity spread across lots worries me more than the molecule does, take that with a pinch of salt

PP

quick one i log resting heart rate every morning because of this and its the one number i actually watch

watching my heart rate

PP

lost 8kg over 19 months at doses well under what the trials used

📈11📉6

cant feel it honestly

RT

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, someone check my working

U1

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

U1

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, anyway

did the phase 2 plateau or was it still moving at the end

PP

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

P2

Janoshik came back 96.8 on one lot and 98.1 on the next from the same WXT, both fine

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

follow up GI was about the same as tirzepatide for me, the difference was how fast it arrived

🧊1📈18👀2
BB

right so stopped for 14 months and restarted at half my old dose, the ramp was easier second time

VB

Batch lookup A-2601: 3 independent reports on file, earliest 2024-12-17.

VB

New independent result logged — WXT, lot G-0641, purity 98.1% (PeptideMeter).

📉1
P2

is there any long term safety data at all or is it phase 2 and hope

held mine ages

BB

people insist on small steps because the side effects arrive faster than on the other two

PP

i said 6 months ago that my heart rate had settled and it has stayed settled since, ill dig out the number

no idea whether the heart rate settles for everyone, mine did and one log isnt data

❤️3
PP

whats the half life like, is it weekly the same way
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

SN

blood pressure stayed flat for me while heart rate moved, which i didnt expect

how slow is low and slow here, four weeks a step or longer