vialroom

#retatrutide 2025-09-07

Sunday45 messages10 participantstimes are UTC
Highlights from this day
  • taper_tess — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 19:28
  • VialBot — On this day 5 years ago this channel logged 90 messages. 20:39
  • ferritin_fay — blood pressure stayed flat for me while heart rate moved, which i didnt expect 21:02
  • hair_month_four — anyone logging resting heart rate on this 21:54
  • truncation_tru — quick one people insist on small steps because the side effects arrive faster than on the other two 22:40
EO

reconstituted the 5 vial to 5mg/ml specifically so i could take 5 without measuring crumbs

RR

stopped for 3 months and restarted at half my old dose, the ramp was easier second time

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EO

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

19:01quiet.hours pinned a message to this channel
TT

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
stepping in 1.7 increments instead of doubling is the only thing i would change if i started again

the purity spread across lots worries me more than the molecule does

no idea whether the heart rate settles for everyone, mine did and one log isnt data

TT

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

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SS

anyone stayed at 1.7 for months rather than climbing

HM

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

HM

is there any long term safety data at all or is it phase 2 and hope

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AP

slightly off topic but appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point, thats one data point

im at 2.5 and the appetite effect is stronger than i expected, normal
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

nobody should read my log as a plan, im recording what i did and thats all it is

SS

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

SB

i log resting heart rate every morning because of this and its the one number i actually watch

mine went up too

VB

On this day 5 years ago this channel logged 90 messages.

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SB

while im here does the energy expenditure claim show up as anything you can feel

RR

the heart rate thing is real enough that i mention it whenever someone asks about starting, for what its worth

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is TRIUMPH the phase 3 programme

FF

blood pressure stayed flat for me while heart rate moved, which i didnt expect

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
FF

the honest position is this has less human evidence behind it than anything else discussed here, take that with a pinch of salt

FF

watching my heart rate

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cant feel it honestly

HM

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

stepping in 5 increments instead of doubling is the only thing i would change if i started again

anyone logging resting heart rate on this

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SS

anyone tracking blood pressure alongside the heart rate

TT

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

SS

my resting rate went up 2 bpm in the first month and came back most of the way by month 7

TT

sat at 5 for 8 months rather than climbing and it kept working, so i never went up, still working it out

quick one people insist on small steps because the side effects arrive faster than on the other two

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TT

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, from memory