phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
#retatrutide 2025-10-06
Monday46 messages9 participantstimes are UTC
Highlights from this day
- alt_ast_ali — right so reconstituted the 15 vial to 4mg/ml specifically so i could take 1 without measuring crumbs 15:55
- juno_joins — stopped for 1 months and restarted at half my old dose, the ramp was easier second time 15:56
- power_through_no — genuine question im at 1 and the appetite effect is stronger than i expected, normal 20:24
does the energy expenditure claim show up as anything you can feel
my resting heart rate is up about 6 bpm, did that settle for anyone
back after 5 months, has anything actually been published since
smaller steps here
low and slow
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, take that with a pinch of salt
settled by month three
did the phase 2 plateau or was it still moving at the end
came off at 7 weeks because my resting rate stayed elevated and i didnt like it
watching my heart rate
is the phase 2 dosing anywhere near what people here run
people insist on small steps because the side effects arrive faster than on the other two, ill dig out the number
[edited]cant feel it honestly
no long term data
glucagon is the new bit
how do people square the research use only framing with logging their own use
is TRIUMPH the phase 3 programme
whats a sensible starting point, im seeing everything from 0.5 to 2
i log resting heart rate every morning because of this and its the one number i actually watch
right so reconstituted the 15 vial to 4mg/ml specifically so i could take 1 without measuring crumbs
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stopped for 1 months and restarted at half my old dose, the ramp was easier second time
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
whats the half life like, is it weekly the same way
i said 8 months ago that my heart rate had settled and it has stayed settled since
how long before people saw the first change at 1.7
anyone logging resting heart rate on this
lost 29kg over 26 months at doses well under what the trials used
the purity spread across lots worries me more than the molecule does
*Medutest not the other one
i log resting heart rate every morning because of this and its the one number i actually watch
did anyone come off because of the heart rate
the honest position is this has less human evidence behind it than anything else discussed here
GI was about the same as tirzepatide for me, the difference was how fast it arrived
research use only
anyone reconstituting 5 vials to 8 so the steps come out smaller
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
my resting rate went up 5 bpm in the first month and came back most of the way by month 9
TRIUMPH is phase 3
does the glucagon arm explain the heart rate or is that unrelated
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Janoshik came back 96.8 on one lot and 99.4 on the next from the same QYB, both fine, i could be wrong
mine went up too
genuine question anyone tracking blood pressure alongside the heart rate
triple agonist yeah
Purity check: no report on file for lot G-0641. Nothing logged either way.
phase 2 only
sat at 1.7 for 3 months rather than climbing and it kept working, so i never went up
genuine question im at 1 and the appetite effect is stronger than i expected, normal
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low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom