low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
#retatrutide 2025-10-09
Thursday39 messages7 participantstimes are UTC
Highlights from this day
- see_a_clinician — GI was about the same as tirzepatide for me, the difference was how fast it arrived, for what its worth 20:12
- non_scale_win — stepping in 0.5 increments instead of doubling is the only thing i would change if i started again 20:24
- see_a_clinician — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 20:29
cant feel it honestly
no idea whether the heart rate settles for everyone, mine did and one log isnt data
did the phase 2 plateau or was it still moving at the end
genuine question nobody should read my log as a plan, im recording what i did and thats all it is
came off at 5 weeks because my resting rate stayed elevated and i didnt like it
triple agonist yeah
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unrelated but how do people square the research use only framing with logging their own use
is the glucagon arm what people mean by the energy expenditure thing
whats the half life like, is it weekly the same way
watching my heart rate
[edited]phase 2 only
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps, for what its worth
held at 0.25 for 10 months and it never plateaued for me, which i cant explain
research use only
anyone stayed at 1 for months rather than climbing
right so the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
mine went up too
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, for what its worth
*Janoshik not the other one
GI was about the same as tirzepatide for me, the difference was how fast it arrived, for what its worth
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the honest position is this has less human evidence behind it than anything else discussed here
anyone reconstituting 30 vials to 4 so the steps come out smaller
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glucagon is the new bit
TRIUMPH is phase 3
anyone gone above 5 and what changed
logging rhr daily
the half life supports weekly dosing and thats what ive done from the start
stepping in 0.5 increments instead of doubling is the only thing i would change if i started again
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)the heart rate thing is real enough that i mention it whenever someone asks about starting
the purity spread across lots worries me more than the molecule does
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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is there any long term safety data at all or is it phase 2 and hope