#retatrutide 2025-11-01

low and slow

anyone logging resting heart rate on this

sorry to jump in appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point

smaller steps here

my resting rate went up 6 bpm in the first month and came back most of the way by month 18

lost 41kg over 19 months at doses well under what the trials used, we shall see

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

right so does the glucagon arm explain the heart rate or is that unrelated

sat at 10 for 2 months rather than climbing and it kept working, so i never went up

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

anyone stayed at 2.5 for months rather than climbing

people insist on small steps because the side effects arrive faster than on the other two

mine went up too

the honest position is this has less human evidence behind it than anything else discussed here
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual

is the phase 2 dosing anywhere near what people here run

the heart rate thing is real enough that i mention it whenever someone asks about starting, we shall see

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

research use only

held mine ages

did the phase 2 result actually come in higher than the tirzepatide numbers

no long term data

nobody should read my log as a plan, im recording what i did and thats all it is

On this day 9 years ago this channel logged 77 messages.

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, for what its worth

Reminder set. I will post here in 2 days.

stepping in 2 increments instead of doubling is the only thing i would change if i started again

how long before people saw the first change at 0.25

logging rhr daily

Batch lookup G-0641: 2 independent reports on file, earliest 2025-09-02.

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

coming back to this the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

Janoshik came back 98.1 on one lot and 96.8 on the next from the same SGN, both fine, anyway

*Medutest not the other one

cant feel it honestly

settled by month three

TRIUMPH is phase 3

for the archive is there any long term safety data at all or is it phase 2 and hope

anyone compared their PeptideMeter purity across two different QST lots

triple agonist yeah

is the glucagon arm what people mean by the energy expenditure thing

i said 2 months ago that my heart rate had settled and it has stayed settled since

came off at 15 weeks because my resting rate stayed elevated and i didnt like it, happy to be corrected

is TRIUMPH the phase 3 programme

whats the half life like, is it weekly the same way
the honest position is this has less human evidence behind it than anything else discussed here

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me