Digest for the week of 2025-08-18 has been published.
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#retatrutide 2025-12-01
Monday26 messages7 participantstimes are UTC
Highlights from this day
- VialBot — Digest for the week of 2025-08-18 has been published. 14:17
- cagri_curious — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, take that with a pinch of salt 15:09
- cagri_curious — nobody should read my log as a plan, im recording what i did and thats all it is 16:22
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
my resting rate went up 3 bpm in the first month and came back most of the way by month 23
held mine ages
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is the GI worse than tirzepatide or about the same
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)glucagon is the new bit
right so lost 13kg over 24 months at doses well under what the trials used
medutest-report-b-0114.pdf
3 pages · 474 KB · not retained in the public archive
did the phase 2 result actually come in higher than the tirzepatide numbers
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blood pressure stayed flat for me while heart rate moved, which i didnt expect, ask me again in a month
the heart rate thing is real enough that i mention it whenever someone asks about starting, thats one data point
settled by month three
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, take that with a pinch of salt
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anyone logging resting heart rate on this
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genuine question how do people square the research use only framing with logging their own use
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
no idea whether the heart rate settles for everyone, mine did and one log isnt data, thats one data point
the honest position is this has less human evidence behind it than anything else discussed here
low and slow
logging rhr daily
slightly off topic but the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
nobody should read my log as a plan, im recording what i did and thats all it is
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mine went up too
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came off at 15 weeks because my resting rate stayed elevated and i didnt like it
no long term data
Purity check: no report on file for lot SG-1177. Nothing logged either way.
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smaller steps here
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phase 2 only