held mine ages
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#retatrutide 2025-12-04
Thursday53 messages10 participantstimes are UTC
Highlights from this day
- tga_notice — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, i have it written down somewhere 22:16
- escalation_anxiety — no idea whether the heart rate settles for everyone, mine did and one log isnt data 22:41
- pinch_not_stretch — how do people square the research use only framing with logging their own use 22:50
- revoked_ro — is there any long term safety data at all or is it phase 2 and hope 22:52
- warsaw_vial — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 23:12
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
watching my heart rate
came off at 9 weeks because my resting rate stayed elevated and i didnt like it
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
unrelated but does the energy expenditure claim show up as anything you can feel
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, i have it written down somewhere
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TRIUMPH is phase 3
does the glucagon arm explain the heart rate or is that unrelated
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
my resting rate went up 3 bpm in the first month and came back most of the way by month 2
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
stopped for 26 months and restarted at half my old dose, the ramp was easier second time, anyway
is the phase 2 dosing anywhere near what people here run
triple agonist yeah
anyone compared their Medutest purity across two different WXT lots
update on the earlier thing the half life supports weekly dosing and thats what ive done from the start
quick one phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
reconstituted the 30 vial to 5mg/ml specifically so i could take 2 without measuring crumbs
PeptideMeter came back 99 on one lot and 99.2 on the next from the same MKM, both fine
whats a sensible starting point, im seeing everything from 0.5 to 2
no idea whether the heart rate settles for everyone, mine did and one log isnt data
nobody should read my log as a plan, im recording what i did and thats all it is
low and slow
stepping in 0.5 increments instead of doubling is the only thing i would change if i started again
held at 2.4 for 6 months and it never plateaued for me, which i cant explain
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
how do people square the research use only framing with logging their own use
😂15📈7🧪2
is there any long term safety data at all or is it phase 2 and hope
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quick one low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
my resting heart rate is up about 2 bpm, did that settle for anyone
smaller steps here
the honest position is this has less human evidence behind it than anything else discussed here
blood pressure stayed flat for me while heart rate moved, which i didnt expect
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glucagon is the new bit
appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point
i log resting heart rate every morning because of this and its the one number i actually watch, i have it written down somewhere
[edited]PeptideMeter came back 97.4 on one lot and 99 on the next from the same JEEP, both fine, i could be wrong
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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*that should say weekly
phase 2 only
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triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
anyone tracking blood pressure alongside the heart rate
anyone stayed at 12 for months rather than climbing
the heart rate thing is real enough that i mention it whenever someone asks about starting
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
slightly off topic but why does everyone insist on smaller steps here than on the other two
*Medutest not the other one
back after 26 months, has anything actually been published since
the purity spread across lots worries me more than the molecule does, for what its worth
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
[edited]