vialroom

#retatrutide 2026-01-20

Tuesday17 messages4 participantstimes are UTC
Highlights from this day
  • taper_or_not — anyone reconstituting 15 vials to 2.5 so the steps come out smaller 18:20
  • lipase_lore — slightly off topic but how slow is low and slow here, four weeks a step or longer 20:53
  • reta_low_dose — follow up anyone tracking blood pressure alongside the heart rate 20:54
TO

anyone reconstituting 15 vials to 2.5 so the steps come out smaller

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
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LL

no idea whether the heart rate settles for everyone, mine did and one log isnt data

LL

people insist on small steps because the side effects arrive faster than on the other two

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

settled by month three

TO

coming back to this i said 8 months ago that my heart rate had settled and it has stayed settled since

TO

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

while im here phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, ask me again in a month

LL

held mine ages

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
LL

how long before people saw the first change at 2.4

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RL

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

LL

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual

LL

glucagon is the new bit

coa-f-1330.pdf
1 page · 205 KB · not retained in the public archive
LL

unrelated but came off at 16 weeks because my resting rate stayed elevated and i didnt like it

LL

slightly off topic but how slow is low and slow here, four weeks a step or longer

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RL

follow up anyone tracking blood pressure alongside the heart rate

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)