is TRIUMPH the phase 3 programme
#retatrutide 2026-02-22
Sunday39 messages6 participantstimes are UTC
Highlights from this day
- travel_cooler — follow up low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 15:43
- thank_you_year_on — im at 2 and the appetite effect is stronger than i expected, normal research use only is on every vial and i treat it as exactly that, nobody here is prescribing 17:14
- triumph_watch — held at 7.5 for 6 months and it never plateaued for me, which i cant explain 17:24
anyone stayed at 2 for months rather than climbing
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
my resting rate went up 5 bpm in the first month and came back most of the way by month 1, for what its worth
GI was about the same as tirzepatide for me, the difference was how fast it arrived
nobody should read my log as a plan, im recording what i did and thats all it is
the heart rate thing is real enough that i mention it whenever someone asks about starting
i said 2 months ago that my heart rate had settled and it has stayed settled since
sorry to jump in anyone logging resting heart rate on this
does the energy expenditure claim show up as anything you can feel
how do people square the research use only framing with logging their own use
[edited]the half life supports weekly dosing and thats what ive done from the start
blood pressure stayed flat for me while heart rate moved, which i didnt expect
stopped for 12 months and restarted at half my old dose, the ramp was easier second time
follow up low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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watching my heart rate
lost 11kg over 11 months at doses well under what the trials used
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
the purity spread across lots worries me more than the molecule does
sat at 0.5 for 4 months rather than climbing and it kept working, so i never went up
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
whats a sensible starting point, im seeing everything from 0.5 to 2
PeptideMeter came back 99.4 on one lot and 99.2 on the next from the same MKM, both fine, not advice obviously
reconstituted the 2 vial to 8mg/ml specifically so i could take 0.25 without measuring crumbs
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
people insist on small steps because the side effects arrive faster than on the other two
im at 2 and the appetite effect is stronger than i expected, normal
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
held at 7.5 for 6 months and it never plateaued for me, which i cant explain
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came off at 8 weeks because my resting rate stayed elevated and i didnt like it
TRIUMPH is phase 3
no idea whether the heart rate settles for everyone, mine did and one log isnt data
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held mine ages
mine went up too
settled by month three
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triple agonist yeah
the honest position is this has less human evidence behind it than anything else discussed here, we shall see
logging rhr daily
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)i log resting heart rate every morning because of this and its the one number i actually watch