sorry to jump in the heart rate thing is real enough that i mention it whenever someone asks about starting
#retatrutide 2026-02-28
Saturday32 messages6 participantstimes are UTC
Highlights from this day
- moss_maintains — i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps 22:53
- VialBot — Inter-lab diff for lot D-0718: 98.6% vs 96.8%. Within expected range. 23:18
- ollie_orders — genuine question anyone gone above 2.4 and what changed 23:21
- VialBot — New independent result logged — SWB, lot G-0641, purity 98.6% (Janoshik). 23:25
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
right so phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, thats just me
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
genuine question how long before people saw the first change at 1.7
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
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blood pressure stayed flat for me while heart rate moved, which i didnt expect
why does everyone insist on smaller steps here than on the other two
watching my heart rate
i log resting heart rate every morning because of this and its the one number i actually watch
whats a sensible starting point, im seeing everything from 0.5 to 2
the purity spread across lots worries me more than the molecule does, still working it out
is the GI worse than tirzepatide or about the same
sorry to jump in stepping in 2.4 increments instead of doubling is the only thing i would change if i started again
nobody should read my log as a plan, im recording what i did and thats all it is
glucagon is the new bit
*Medutest not the other one
coming back to this there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
anyone logging resting heart rate on this
Inter-lab diff for lot D-0718: 98.6% vs 96.8%. Within expected range.
genuine question anyone gone above 2.4 and what changed
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for the archive the honest position is this has less human evidence behind it than anything else discussed here
New independent result logged — SWB, lot G-0641, purity 98.6% (Janoshik).
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is there any long term safety data at all or is it phase 2 and hope
how do people square the research use only framing with logging their own use
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, ymmv
logging rhr daily
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
held at 2 for 11 months and it never plateaued for me, which i cant explain
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
Inter-lab diff for lot A-2418: 96.8% vs 99.4%. Within expected range.
TRIUMPH is phase 3
genuine question buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
phase 2 only