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#retatrutide 2026-03-06

Friday19 messages4 participantstimes are UTC
Highlights from this day
  • ghk_gia — im at 5 and the appetite effect is stronger than i expected, normal 21:51
  • nhs_pathway_nell — sat at 2.5 for 7 months rather than climbing and it kept working, so i never went up 21:52
  • bac_water_bill — stepping in 2.5 increments instead of doubling is the only thing i would change if i started again 22:45
NP

people insist on small steps because the side effects arrive faster than on the other two

GG

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

GG

the purity spread across lots worries me more than the molecule does, i think

im at 5 and the appetite effect is stronger than i expected, normal

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NP

sat at 2.5 for 7 months rather than climbing and it kept working, so i never went up

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NP

appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point

NP

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

BW

GI was about the same as tirzepatide for me, the difference was how fast it arrived

BW

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

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how slow is low and slow here, four weeks a step or longer

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
NP

Janoshik came back 98.6 on one lot and 99.4 on the next from the same SGN, both fine

BW

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ymmv

whats the half life like, is it weekly the same way

stepping in 2.5 increments instead of doubling is the only thing i would change if i started again

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