vialroom

#retatrutide 2026-03-17

Tuesday29 messages8 participantstimes are UTC
Highlights from this day
  • declared_value — anyone reconstituting 15 vials to 2 so the steps come out smaller 19:16
  • seizure_letter — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists 19:28
  • chlorhex — GI was about the same as tirzepatide for me, the difference was how fast it arrived 21:12
DV

the half life supports weekly dosing and thats what ive done from the start

SL

anyone compared their PeptideMeter purity across two different GGPeps lots

DV

anyone reconstituting 15 vials to 2 so the steps come out smaller

📉18👍1

does the glucagon arm explain the heart rate or is that unrelated

T5

is there any long term safety data at all or is it phase 2 and hope

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
SL

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
🧊1🔥2
SL

nobody should read my log as a plan, im recording what i did and thats all it is
the half life supports weekly dosing and thats what ive done from the start

i said 2 months ago that my heart rate had settled and it has stayed settled since

DV

stepping in 1.7 increments instead of doubling is the only thing i would change if i started again

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
VB

Channel stats, last 30 days: 32 messages from 28 members.

FN

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

KF

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

CH

GI was about the same as tirzepatide for me, the difference was how fast it arrived

🤝15❤️14
CH

the heart rate thing is real enough that i mention it whenever someone asks about starting

glucagon is the new bit

👀15⚠️8🤝1

did anyone come off because of the heart rate

🧊5🙏6
SL

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

SL

the honest position is this has less human evidence behind it than anything else discussed here

CH

coming back to this PeptideMeter came back 99.4 on one lot and 98.6 on the next from the same FGP, both fine

FN

came off at 7 weeks because my resting rate stayed elevated and i didnt like it

lost 23kg over 8 months at doses well under what the trials used

[edited]