follow up the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
#retatrutide 2026-03-29
Sunday39 messages9 participantstimes are UTC
Highlights from this day
- comment_fatigue — sat at 2 for 5 months rather than climbing and it kept working, so i never went up 11:23
- comment_fatigue — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 11:24
- sharps_bin_sid — VendorInvestigate came back 98.6 on one lot and 98.1 on the next from the same ERP, both fine 13:16
smaller steps here
is the phase 2 dosing anywhere near what people here run
research use only
stopped for 21 months and restarted at half my old dose, the ramp was easier second time
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
does the energy expenditure claim show up as anything you can feel
stepping in 0.5 increments instead of doubling is the only thing i would change if i started again, not advice obviously
pinch_not_stretchstopped for 21 months and restarted at half my old dose, the ramp was easier second time
for the archive back after 20 months, has anything actually been published since
whats a sensible starting point, im seeing everything from 0.5 to 2
my resting heart rate is up about 3 bpm, did that settle for anyone
slightly off topic but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
the honest position is this has less human evidence behind it than anything else discussed here
GI was about the same as tirzepatide for me, the difference was how fast it arrived
genuine question how long before people saw the first change at 1.7
i said 7 months ago that my heart rate had settled and it has stayed settled since
the honest position is this has less human evidence behind it than anything else discussed here
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
settled by month three
logging rhr daily
right so the half life supports weekly dosing and thats what ive done from the start
slightly off topic but anyone tracking blood pressure alongside the heart rate
GI was about the same as tirzepatide for me, the difference was how fast it arrived
the heart rate thing is real enough that i mention it whenever someone asks about starting
no idea whether the heart rate settles for everyone, mine did and one log isnt data
held at 10 for 14 months and it never plateaued for me, which i cant explain
i log resting heart rate every morning because of this and its the one number i actually watch
sat at 2 for 5 months rather than climbing and it kept working, so i never went up
[edited]coa-f-1330.pdf
1 page · 298 KB · not retained in the public archive
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
🤝1⚠️7
TRIUMPH is phase 3
phase 2 only
anyone compared their VendorInvestigate purity across two different KP lots
genuine question whats the half life like, is it weekly the same way
no long term data
research use only is on every vial and i treat it as exactly that, nobody here is prescribing, ymmv
my resting rate went up 5 bpm in the first month and came back most of the way by month 15
low and slow
mine went up too
Channel stats, last 30 days: 115 messages from 56 members.
did the phase 2 result actually come in higher than the tirzepatide numbers
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
people insist on small steps because the side effects arrive faster than on the other two
VendorInvestigate came back 98.6 on one lot and 98.1 on the next from the same ERP, both fine
🤝10