TRIUMPH is phase 3
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#retatrutide 2026-03-31
Tuesday54 messages11 participantstimes are UTC
Highlights from this day
- unsolicited_dm — did anyone come off because of the heart rate 21:41
- endotoxin_ed — im at 10 and the appetite effect is stronger than i expected, normal 21:59
- abdo_two_inch — for the archive low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 22:14
- fake_tracking — anyone gone above 1 and what changed 23:28
the honest position is this has less human evidence behind it than anything else discussed here
anyone compared their Medutest purity across two different Homopeptide lots
the heart rate thing is real enough that i mention it whenever someone asks about starting, anyway
whats a sensible starting point, im seeing everything from 0.5 to 2
did anyone come off because of the heart rate
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)my resting rate went up 4 bpm in the first month and came back most of the way by month 16, your mileage will differ
smaller steps here
watching my heart rate
settled by month three
does the energy expenditure claim show up as anything you can feel
whats the half life like, is it weekly the same way
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
quick one research use only is on every vial and i treat it as exactly that, nobody here is prescribing
im at 10 and the appetite effect is stronger than i expected, normal
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quick one appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, for what its worth
[edited]triple agonist yeah
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genuine question the purity spread across lots worries me more than the molecule does, anyway
did the phase 2 result actually come in higher than the tirzepatide numbers
GI was about the same as tirzepatide for me, the difference was how fast it arrived
PeptideMeter came back 99.4 on one lot and 98.1 on the next from the same JEEP, both fine
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
for the archive low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)sorry to jump in reconstituted the 15 vial to 5mg/ml specifically so i could take 2.5 without measuring crumbs
is the phase 2 dosing anywhere near what people here run
how long before people saw the first change at 0.5
people insist on small steps because the side effects arrive faster than on the other two
for the archive is TRIUMPH the phase 3 programme
did the phase 2 plateau or was it still moving at the end
genuine question stopped for 14 months and restarted at half my old dose, the ramp was easier second time
glucagon is the new bit
why does everyone insist on smaller steps here than on the other two
Purity check: no report on file for lot E-2205. Nothing logged either way.
blood pressure stayed flat for me while heart rate moved, which i didnt expect
lost 11kg over 12 months at doses well under what the trials used, anyway
how do people square the research use only framing with logging their own use
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i said 2 months ago that my heart rate had settled and it has stayed settled since
reconstituted the 40 vial to 2mg/ml specifically so i could take 7.5 without measuring crumbs
low and slow
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
for the archive stepping in 10 increments instead of doubling is the only thing i would change if i started again
[edited]anyone stayed at 5 for months rather than climbing
held mine ages
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follow up phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, anyway
is there any long term safety data at all or is it phase 2 and hope
lost 21kg over 11 months at doses well under what the trials used
unrelated but how slow is low and slow here, four weeks a step or longer
[edited]Testing queue: 7 submissions open, 89 awaiting dispatch.
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
[edited]no long term data
anyone gone above 1 and what changed
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mine went up too
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
logging rhr daily
nobody should read my log as a plan, im recording what i did and thats all it is
is the glucagon arm what people mean by the energy expenditure thing