#semaglutide 2024-01-13

Saturday18 messages5 participantstimes are UTC

Highlights from this day

LC_MS_Lena — while im here how many weeks before you noticed anything at 2.4 22:37
vialkeeper — follow up how long till steady state, ive read the half life is about a week 22:40
vial_ledger — i held at 1.7 for 5 months and it was the best decision i made 22:59
noct.titrate — changed my mind on the four week rule, i think it depends entirely on how the current dose feels, still working it out 23:38

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

half life is about a week so youre roughly four to five weeks to steady state on any new dose

dose day is sunday for me only because thats when i remember, not because sunday matters

slightly off topic but does the licensed ceiling for weight differ from the diabetes one

not the same trial

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

while im here how many weeks before you noticed anything at 2.4

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

moving my dose day by a day or two never did anything noticeable for me

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, thats one data point

follow up how long till steady state, ive read the half life is about a week

🙏5👀3

vial units and pen clicks are different systems, mixing the two is how people end up wrong

STEP is several trials, so saying STEP said x is usually wrong without a number after it

i held at 1.7 for 5 months and it was the best decision i made

medutest-report-b-0329.pdf

3 pages · 812 KB · not retained in the public archive

i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it, we shall see

does moving my dose day by two days matter with a seven day half life

whats the actual licensed ceiling, i keep seeing different numbers

changed my mind on the four week rule, i think it depends entirely on how the current dose feels, still working it out

did anyone hold at 2 longer than four weeks before going up