plateaus move
#semaglutide 2024-03-28
Thursday15 messages5 participantstimes are UTC
Highlights from this day
- batch_bandit — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, ill dig out the number 15:28
- batch_bandit — right so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 17:04
- karl_fischer — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 17:29
what did SELECT actually measure, i see it quoted for everything
seven days ish
vials not pens here
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
not the same trial
my 10 vial in 5ml gives 8mg/ml so 7.5 lands on 12 units, thats why i picked that volume
whats the actual licensed ceiling, i keep seeing different numbers
anyone compared their 5 vial dosing against the pen increments
mine faded too
STEP is several trials, so saying STEP said x is usually wrong without a number after it
right so steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
the long half life flattens the trough more than people expect, i never felt a day seven dip