the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, n of 1 obviously
#semaglutide 2024-05-04
Saturday27 messages7 participantstimes are UTC
Highlights from this day
- split_dose_sam — the long half life flattens the trough more than people expect, i never felt a day seven dip 07:53
- bea_reconstitutes — im 18 months in at 10 and the appetite effect faded, is that a thing 08:13
- VialBot — Inter-lab diff for lot H-2814: 98.1% vs 99%. Within expected range. 11:47
- VialBot — Assay note: QST lot A-2418 reported at 98.6% of label content. 12:12
slower worked better
five week steps worked better for me than four, purely on how the second week felt
what did SELECT actually measure, i see it quoted for everything
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did the STEP 4 withdrawal arm show what i think it showed
the long half life flattens the trough more than people expect, i never felt a day seven dip
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whats the actual licensed ceiling, i keep seeing different numbers
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07:56quiet.hours pinned a message
did anyone titrate slower than four weeks a step and how did that go
24 months at 2.4 and the honest summary is diminishing returns after the first half
im 18 months in at 10 and the appetite effect faded, is that a thing
transit-times.csv
142 rows · not retained in the public archive
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coming back to this back after 9 months off, do i restart at 0.25 or somewhere higher
slightly off topic but STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
went too fast once
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, n of 1 obviously
SELECT wasnt weight
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
steady state takes weeks
how did people handle the jump from 1 to 1.7
lot-log.csv
362 rows · not retained in the public archive
seven days ish
held at 0.5 and lost 79lb over 18 months, slower than the trials and fine by me
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, take that with a pinch of salt
the appetite effect faded for me around 3 months and going up fixed it for a while
STEP 1 ran to 68 weeks. thats the one everyone half remembers
Inter-lab diff for lot H-2814: 98.1% vs 99%. Within expected range.
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Assay note: QST lot A-2418 reported at 98.6% of label content.
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moving my dose day by a day or two never did anything noticeable for me, n of 1 obviously