held at 2.5 and lost 54lb over 1 months, slower than the trials and fine by me
#semaglutide 2024-06-04
Tuesday38 messages8 participantstimes are UTC
Highlights from this day
- mg_per_ml — vial units and pen clicks are different systems, mixing the two is how people end up wrong 10:18
- taper_tess — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 11:19
- taper_tess — did anyone hold at 2 longer than four weeks before going up compounded and brand felt the same to me at 1.7, which is one person and nothing more 11:59
- swirl_not_shake — i dont think the plateau is a dose problem most of the time, but i cant prove that 12:53
did anyone titrate slower than four weeks a step and how did that go
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
sorry to jump in the appetite effect faded for me around 7 months and going up fixed it for a while
anyone gone from 2.5 straight to 1.7 or is that too big a jump
does the licensed ceiling for weight differ from the diabetes one
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, anyway
moving my dose day by a day or two never did anything noticeable for me
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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my 30 vial in 3ml gives 2mg/ml so 1.7 lands on 40 units, thats why i picked that volume
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
ok so 11 months at 2.4 and the honest summary is diminishing returns after the first half
is the plateau usually appetite coming back or just the scale stopping
follow up if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP 1 ran to 68 weeks. thats the one everyone half remembers
did anyone hold at 2 longer than four weeks before going up
compounded and brand felt the same to me at 1.7, which is one person and nothing more
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compounded and brand felt the same to me at 2.4, which is one person and nothing more
SELECT wasnt weight
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mine faded too
how many weeks before you noticed anything at 10
my PeptideMeter report on the QYB vial came back 98.1 against a certificate saying 99
£120 a month for compounded against what brand costs locally is why most people here use vials, ill dig out the number
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
seven days ish
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the plateau hit me at 32 weeks and moved again about a month later without a dose change
pinch_not_stretch£120 a month for compounded against what brand costs locally is why most people here…
five week steps worked better for me than four, purely on how the second week felt, i have it written down somewhere
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, thats just me
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
lost about 46kg on the low doses before i even got to 1, which surprised me
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping, for what its worth
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
dose day is sunday for me only because thats when i remember, not because sunday matters, i think
i dont think the plateau is a dose problem most of the time, but i cant prove that
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held there too
i stayed on 1.7 for 2 months and never went to 2.4, appetite was already where i needed it, not advice obviously
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