coming back to this i dont think the plateau is a dose problem most of the time, but i cant prove that
#semaglutide 2024-06-12
Wednesday37 messages9 participantstimes are UTC
Highlights from this day
- VialBot — Batch lookup KP-0925: 6 independent reports on file, earliest 2024-03-26. 20:42
- week_three_wall — moving my dose day by a day or two never did anything noticeable for me half life is about a week so youre roughly four to five weeks to steady state on any new dose 20:51
- VialBot — Reminder set. I will post here in 9 days. 21:18
- VialBot — New independent result logged — SSA, lot H-2814, purity 98.1% (Janoshik). 22:11
- vial_ledger — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 23:16
is 2.4 the top or do people go past it
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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the long half life flattens the trough more than people expect, i never felt a day seven dip
plateaus move
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held at 7.5 and lost 55lb over 11 months, slower than the trials and fine by me
vial units and pen clicks are different systems, mixing the two is how people end up wrong
£185 a month for compounded against what brand costs locally is why most people here use vials
same dose day
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
sorry to jump in i stayed on 1.7 for 15 months and never went to 2.4, appetite was already where i needed it
half life is about a week so youre roughly four to five weeks to steady state on any new dose
lost about 32kg on the low doses before i even got to 1, which surprised me
20:27quiet.hours pinned a message
did the STEP 4 withdrawal arm show what i think it showed
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
dose day is sunday for me only because thats when i remember, not because sunday matters
steady state takes weeks
Batch lookup KP-0925: 6 independent reports on file, earliest 2024-03-26.
moving my dose day by a day or two never did anything noticeable for me
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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thats STEP 1
vial units and pen clicks are different systems, mixing the two is how people end up wrong
[redacted at member request] · archive policy
Reminder set. I will post here in 9 days.
2.4 is the ceiling
21:38quiet.hours pinned a message
back after 8 months off, do i restart at 0.25 or somewhere higher
SELECT wasnt weight
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compounded and brand felt the same to me at 1, which is one person and nothing more
anyone compared their 10 vial dosing against the pen increments
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, thats one data point
mine faded too
New independent result logged — SSA, lot H-2814, purity 98.1% (Janoshik).
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the appetite effect faded for me around 10 months and going up fixed it for a while
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
im at 10 and stuck, did anyone break a plateau without going up
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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slightly off topic but if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, n of 1 obviously