did the STEP 4 withdrawal arm show what i think it showed
#semaglutide 2024-06-17
Monday26 messages8 participantstimes are UTC
Highlights from this day
- split_dose_sam — five week steps worked better for me than four, purely on how the second week felt, thats just me 18:17
- typosquat_tay — my PeptideMeter report on the KP vial came back 99.2 against a certificate saying 99 19:11
- typosquat_tay — the long half life flattens the trough more than people expect, i never felt a day seven dip 19:25
- protein_floor — quick one anyone gone from 2.5 straight to 15 or is that too big a jump 19:29
- u100_pat — lost about 28kg on the low doses before i even got to 1, which surprised me steady state is the bit people skip, judging a new dose after eight days tells you almost… 19:58
seven days ish
five week steps worked better for me than four, purely on how the second week felt, thats just me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
was STEP 4 the one that ran to 68 weeks or am i mixing them up
what did SELECT actually measure, i see it quoted for everything
2.4 is the ceiling
same dose day
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
right so licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
my PeptideMeter report on the KP vial came back 99.2 against a certificate saying 99
half life is about a week so youre roughly four to five weeks to steady state on any new dose, thats just me
i dont think the plateau is a dose problem most of the time, but i cant prove that
went too fast once
follow up STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
the long half life flattens the trough more than people expect, i never felt a day seven dip
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dose day is sunday for me only because thats when i remember, not because sunday matters
quick one anyone gone from 2.5 straight to 15 or is that too big a jump
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whats the actual licensed ceiling, i keep seeing different numbers
[edited]does moving my dose day by two days matter with a seven day half life
14 months at 2.4 and the honest summary is diminishing returns after the first half
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, thats one data point
[edited]lost about 28kg on the low doses before i even got to 1, which surprised me
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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is the plateau usually appetite coming back or just the scale stopping
moving my dose day by a day or two never did anything noticeable for me
does the seven day half life mean the last two days are weaker
did anyone titrate slower than four weeks a step and how did that go
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