if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, ymmv
#semaglutide 2024-08-10
Saturday41 messages8 participantstimes are UTC
Highlights from this day
- rotate_the_site — did the STEP 4 withdrawal arm show what i think it showed 11:37
- vial_ledger — follow up held at 2.4 and lost 25lb over 11 months, slower than the trials and fine by me the appetite effect faded for me around 2 months and going up fixed it for a… 11:40
- area_percent — half life is about a week so youre roughly four to five weeks to steady state on any new dose 18:24
plateaus move
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does the seven day half life mean the last two days are weaker
the appetite effect faded for me around 20 months and going up fixed it for a while
my dose day drifted from friday to sunday, does that reset anything
did the STEP 4 withdrawal arm show what i think it showed
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*Medutest not the other one
follow up held at 2.4 and lost 25lb over 11 months, slower than the trials and fine by me
the appetite effect faded for me around 2 months and going up fixed it for a while
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
same dose day
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im 25 months in at 7.5 and the appetite effect faded, is that a thing
thats STEP 1
the long half life flattens the trough more than people expect, i never felt a day seven dip, ask me again in a month
does anyone actually run a five week step instead of four
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
[edited]21 months at 2.4 and the honest summary is diminishing returns after the first half
genuine question the plateau hit me at 4 weeks and moved again about a month later without a dose change
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is the plateau usually appetite coming back or just the scale stopping
vials not pens here
for the archive im at 2.4 and stuck, did anyone break a plateau without going up
SELECT wasnt weight
steady state takes weeks
how long did the first 41kg take for people at the low doses
ok so anyone compared their 2 vial dosing against the pen increments
unrelated but dose day is sunday for me only because thats when i remember, not because sunday matters, happy to be corrected
held at 10 and lost 97lb over 18 months, slower than the trials and fine by me
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i dont think the plateau is a dose problem most of the time, but i cant prove that
STEP is several trials, so saying STEP said x is usually wrong without a number after it
for the archive STEP 1 ran to 68 weeks. thats the one everyone half remembers, someone check my working
slightly off topic but restarted after 22 months off at a low dose and the nausea arrived exactly like the first time
does moving my dose day by two days matter with a seven day half life
[edited]did anybody find a difference between Homopeptide and pharmacy at the same 2
anyone gone from 2 straight to 12 or is that too big a jump
follow up how many weeks before you noticed anything at 7.5
how long till steady state, ive read the half life is about a week
does the licensed ceiling for weight differ from the diabetes one
my 15 vial in 1.5ml gives 2.5mg/ml so 2.4 lands on 25 units, thats why i picked that volume
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the appetite effect faded for me around 20 months and going up fixed it for a while
€55 a month for compounded against what brand costs locally is why most people here use vials
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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