vialroom

#semaglutide 2024-09-10

Tuesday11 messages6 participantstimes are UTC
Highlights from this day
  • ten_of_ten — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 18:44
  • two_four_ceiling — did the STEP 4 withdrawal arm show what i think it showed 19:05
  • surpass_two — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 19:59
  • VialBot — Testing queue: 5 submissions open, 93 awaiting dispatch. 20:42
TO

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

TF

did the STEP 4 withdrawal arm show what i think it showed

Trial scheduleWhat most people here do
Step interval4 weeks, fixed4-12 weeks, on symptoms
Holdingprotocol deviationnormal and expected
Top dosereached by designoften never reached
Coming downnot studiedcommon at maintenance
ST

moving my dose day by a day or two never did anything noticeable for me

ST

changed my mind on the four week rule, i think it depends entirely on how the current dose feels

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.

the plateau hit me at 5 weeks and moved again about a month later without a dose change

BB

sorry to jump in did anyone titrate slower than four weeks a step and how did that go

TF

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

VB

Testing queue: 5 submissions open, 93 awaiting dispatch.