12 months at 2.4 and the honest summary is diminishing returns after the first half
#semaglutide 2024-10-02
Wednesday27 messages6 participantstimes are UTC
Highlights from this day
- truncation_tru — ok so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial STEP 4 had the withdrawal arm, thats the one people quote… 22:13
- truncation_tru — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 22:20
- truncation_tru — my VendorInvestigate report on the CPC vial came back 99.4 against a certificate saying 99.2 22:21
- eight_mm — the plateau hit me at 20 weeks and moved again about a month later without a dose change 22:27
- eight_mm — did anybody find a difference between SSA and pharmacy at the same 1 22:35
i held at 12 for 4 months and it was the best decision i made
compounded and brand felt the same to me at 15, which is one person and nothing more
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
is the plateau at 30 weeks normal or am i doing something wrong
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
ok so SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
STEP 1 ran to 68 weeks. thats the one everyone half remembers
five week steps worked better for me than four, purely on how the second week felt
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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my VendorInvestigate report on the CPC vial came back 99.4 against a certificate saying 99.2
the plateau hit me at 20 weeks and moved again about a month later without a dose change
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg*week 9 not week 4
did anybody find a difference between SSA and pharmacy at the same 1
what did SELECT actually measure, i see it quoted for everything
vial units and pen clicks are different systems, mixing the two is how people end up wrong
restarted after 3 months off at a low dose and the nausea arrived exactly like the first time
does the seven day half life mean the last two days are weaker
im at 2.4 and stuck, did anyone break a plateau without going up
the appetite effect faded for me around 21 months and going up fixed it for a while, ill dig out the number
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
same dose day
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP is several trials, so saying STEP said x is usually wrong without a number after it
2.4 is the ceiling
update on the earlier thing did the STEP 4 withdrawal arm show what i think it showed
give it four weeks
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does the licensed ceiling for weight differ from the diabetes one