quick one brand vs compounded, is there a difference people can actually feel
#semaglutide 2024-11-16
Saturday50 messages12 participantstimes are UTC
Highlights from this day
- two_four_ceiling — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 17:49
- bac_water_bill — genuine question held at 5 and lost 49lb over 9 months, slower than the trials and fine by me 18:54
- peak_split — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 19:45
- VialBot — Verification log updated: QSC — evidence added, status unchanged. 20:07
- hair_month_four — five week steps worked better for me than four, purely on how the second week felt 20:26
while im here vial units and pen clicks are different systems, mixing the two is how people end up wrong
update on the earlier thing the plateau hit me at 19 weeks and moved again about a month later without a dose change
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
dose day is sunday for me only because thats when i remember, not because sunday matters
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
is there a reason to hold at 1.7 rather than going to 2.4
five week steps worked better for me than four, purely on how the second week felt
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, not advice obviously
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, ask me again in a month
plateaus move
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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i held at 0.5 for 4 months and it was the best decision i made
went too fast once
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22 months at 2.4 and the honest summary is diminishing returns after the first half
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
i dont think the plateau is a dose problem most of the time, but i cant prove that, i could be wrong
the appetite effect faded for me around 21 months and going up fixed it for a while
half life is about a week so youre roughly four to five weeks to steady state on any new dose, for what its worth
[edited]€38 a month for compounded against what brand costs locally is why most people here use vials
slightly off topic but compounded and brand felt the same to me at 1.7, which is one person and nothing more
vials not pens here
how many weeks before you noticed anything at 2
$120 a month for compounded against what brand costs locally is why most people here use vials
held there too
does the licensed ceiling for weight differ from the diabetes one
genuine question held at 5 and lost 49lb over 9 months, slower than the trials and fine by me
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
did the STEP 4 withdrawal arm show what i think it showed
is the plateau at 7 weeks normal or am i doing something wrong
SELECT wasnt weight
two_four_ceilingwent to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
slower worked better
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
seven days ish
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
lost about 33kg on the low doses before i even got to 1, which surprised me
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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how long did the first 30kg take for people at the low doses
STEP 1 ran to 68 weeks. thats the one everyone half remembers
moving my dose day by a day or two never did anything noticeable for me
Verification log updated: QSC — evidence added, status unchanged.
the long half life flattens the trough more than people expect, i never felt a day seven dip
five week steps worked better for me than four, purely on how the second week felt
right so STEP is several trials, so saying STEP said x is usually wrong without a number after it
[edited]whats the actual licensed ceiling, i keep seeing different numbers
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
steady state takes weeks
does the seven day half life mean the last two days are weaker
*PeptideMeter not the other one
how did people handle the jump from 1 to 1.7
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ
thats STEP 1
did anyone hold at 0.25 longer than four weeks before going up