my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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#semaglutide 2024-11-18
Monday39 messages8 participantstimes are UTC
Highlights from this day
- step_one_sian — what did SELECT actually measure, i see it quoted for everything 12:37
- electrolyte_eli — the long half life flattens the trough more than people expect, i never felt a day seven dip 13:25
- cagri_curious — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 18:22
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
my 40 vial in 2ml gives 4mg/ml so 10 lands on 10 units, thats why i picked that volume
*mg/ml, obviously
how many weeks before you noticed anything at 0.5
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
i held at 1.7 for 5 months and it was the best decision i made, ask me again in a month
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgsame dose day
the plateau hit me at 6 weeks and moved again about a month later without a dose change
what did SELECT actually measure, i see it quoted for everything
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vial units and pen clicks are different systems, mixing the two is how people end up wrong, take that with a pinch of salt
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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how long till steady state, ive read the half life is about a week
did anyone hold at 2.4 longer than four weeks before going up
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update on the earlier thing £38 a month for compounded against what brand costs locally is why most people here use vials
dose day is sunday for me only because thats when i remember, not because sunday matters
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the long half life flattens the trough more than people expect, i never felt a day seven dip
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i stayed on 1.7 for 8 months and never went to 2.4, appetite was already where i needed it, not advice obviously
[edited]how did people handle the jump from 1 to 1.7
i dont think the plateau is a dose problem most of the time, but i cant prove that, from memory
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lost about 21kg on the low doses before i even got to 1, which surprised me
half life is about a week so youre roughly four to five weeks to steady state on any new dose, happy to be corrected
back after 1 months off, do i restart at 0.25 or somewhere higher
is there a reason to hold at 1.7 rather than going to 2.4
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whats the actual licensed ceiling, i keep seeing different numbers
does moving my dose day by two days matter with a seven day half life
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held at 1.7 and lost 51lb over 16 months, slower than the trials and fine by me
not the same trial
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
mine faded too
SELECT wasnt weight
steady state takes weeks
anyone gone from 0.25 straight to 5 or is that too big a jump
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
coming back to this is the plateau at 22 weeks normal or am i doing something wrong
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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does the seven day half life mean the last two days are weaker
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution