#semaglutide 2024-12-11

held there too

quick one changed my mind on the four week rule, i think it depends entirely on how the current dose feels

sorry to jump in £240 a month for compounded against what brand costs locally is why most people here use vials

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

my 2 vial in 1.5ml gives 5mg/ml so 0.25 lands on 15 units, thats why i picked that volume

i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
the plateau hit me at 4 weeks and moved again about a month later without a dose change

five week steps worked better for me than four, purely on how the second week felt

im 14 months in at 2.4 and the appetite effect faded, is that a thing

for the archive compounded and brand felt the same to me at 1.7, which is one person and nothing more

brand vs compounded, is there a difference people can actually feel

vials not pens here

give it four weeks

im at 1.7 and stuck, did anyone break a plateau without going up

lost about 23kg on the low doses before i even got to 1, which surprised me

STEP is several trials, so saying STEP said x is usually wrong without a number after it

was STEP 1 the one that ran to 68 weeks or am i mixing them up

i dont think the plateau is a dose problem most of the time, but i cant prove that, your mileage will differ

plateaus move

whats the actual licensed ceiling, i keep seeing different numbers

STEP 1 ran to 68 weeks. thats the one everyone half remembers

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication

quick one my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

i held at 1.7 for 2 months and it was the best decision i made

my PeptideMeter report on the KP vial came back 99.4 against a certificate saying 96.8

vial units and pen clicks are different systems, mixing the two is how people end up wrong

steady state is the bit people skip, judging a new dose after eight days tells you almost nothing

half life is about a week so youre roughly four to five weeks to steady state on any new dose

Recon calculator: 5mg in 0.5ml = 10mg/ml.