i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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#semaglutide 2024-12-13
Friday32 messages6 participantstimes are UTC
Highlights from this day
- week_three_wall — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 08:29
- fibre_first — does the licensed ceiling for weight differ from the diabetes one 08:45
- vienna_vial — did anybody find a difference between Homopeptide and pharmacy at the same 7.5 11:24
- a1c_lag — STEP 1 ran to 68 weeks. thats the one everyone half remembers 12:22
not the same trial
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does the licensed ceiling for weight differ from the diabetes one
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the plateau hit me at 34 weeks and moved again about a month later without a dose change
the appetite effect faded for me around 24 months and going up fixed it for a while, i think
i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
right so what did SELECT actually measure, i see it quoted for everything
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seven days ish
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week_three_wallhalf life is about a week so youre roughly four to five weeks to steady state on any…
did the STEP 4 withdrawal arm show what i think it showed
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
moving my dose day by a day or two never did anything noticeable for me
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thats STEP 1
held at 2.5 and lost 95lb over 12 months, slower than the trials and fine by me
did anyone hold at 5 longer than four weeks before going up
SELECT wasnt weight
went too fast once
slower worked better
did anybody find a difference between Homopeptide and pharmacy at the same 7.5
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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vials not pens here
steady state takes weeks
mine faded too
$94 a month for compounded against what brand costs locally is why most people here use vials, ymmv
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
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same dose day
give it four weeks
compounded and brand felt the same to me at 2, which is one person and nothing more
2.4 is the ceiling