coming back to this dose day is sunday for me only because thats when i remember, not because sunday matters, ill dig out the number
#semaglutide 2025-02-15
Saturday44 messages12 participantstimes are UTC
Highlights from this day
- area_percent — did anybody find a difference between QST and pharmacy at the same 2 17:22
- area_percent — how long did the first 26kg take for people at the low doses five week steps worked better for me than four, purely on how the second week felt 18:47
- homa_ir_hugo — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 19:38
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
my 2 vial in 1.5ml gives 4mg/ml so 7.5 lands on 30 units, thats why i picked that volume
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slightly off topic but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, n of 1 obviously
moving my dose day by a day or two never did anything noticeable for me
20 months at 2.4 and the honest summary is diminishing returns after the first half, take that with a pinch of salt
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, your mileage will differ
does moving my dose day by two days matter with a seven day half life
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the appetite effect faded for me around 20 months and going up fixed it for a while, still working it out
€120 a month for compounded against what brand costs locally is why most people here use vials
same dose day
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give it four weeks
mine faded too
i held at 2 for 6 months and it was the best decision i made
held at 10 and lost 55lb over 20 months, slower than the trials and fine by me
how many weeks before you noticed anything at 7.5
2.4 is the ceiling
how long till steady state, ive read the half life is about a week
five week steps worked better for me than four, purely on how the second week felt
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is there a reason to hold at 1.7 rather than going to 2.4
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
transit-times.csv
453 rows · not retained in the public archive
coming back to this the long half life flattens the trough more than people expect, i never felt a day seven dip
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five week steps worked better for me than four, purely on how the second week felt
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did anybody find a difference between QST and pharmacy at the same 2
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held there too
vial units and pen clicks are different systems, mixing the two is how people end up wrong, ymmv
weights-monthly.csv
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, anyway
was STEP 1 the one that ran to 68 weeks or am i mixing them up
does the seven day half life mean the last two days are weaker
did anyone titrate slower than four weeks a step and how did that go
lost about 29kg on the low doses before i even got to 1, which surprised me
i stayed on 1.7 for 13 months and never went to 2.4, appetite was already where i needed it
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghow long did the first 26kg take for people at the low doses
five week steps worked better for me than four, purely on how the second week felt
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vials not pens here
STEP 1 ran to 68 weeks. thats the one everyone half remembers
$120 a month for compounded against what brand costs locally is why most people here use vials
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whats the actual licensed ceiling, i keep seeing different numbers
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is 2.4 the top or do people go past it
did the STEP 4 withdrawal arm show what i think it showed
the long half life flattens the trough more than people expect, i never felt a day seven dip
went too fast once
compounded and brand felt the same to me at 7.5, which is one person and nothing more
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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brand vs compounded, is there a difference people can actually feel