thats STEP 1
🔥15📈1🧊14
#semaglutide 2025-03-14
Friday54 messages11 participantstimes are UTC
Highlights from this day
- quiet.hours — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 19:58
- hair_month_four — does the seven day half life mean the last two days are weaker 20:23
- nausea_window — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 20:37
- hair_month_four — does anyone actually run a five week step instead of four 22:18
- gradient_greg — slightly off topic but did the STEP 4 withdrawal arm show what i think it showed 22:20
vials not pens here
i dont think the plateau is a dose problem most of the time, but i cant prove that
7 months at 2.4 and the honest summary is diminishing returns after the first half
compounded and brand felt the same to me at 10, which is one person and nothing more, i have it written down somewhere
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
👍12
STEP 1 ran to 68 weeks. thats the one everyone half remembers
2.4 is the ceiling
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
give it four weeks
is the plateau usually appetite coming back or just the scale stopping
does the seven day half life mean the last two days are weaker
[edited]🎉17✅1🧪1
Verification log updated: GL Biochem — evidence added, status unchanged.
STEP is several trials, so saying STEP said x is usually wrong without a number after it
sorry to jump in restarted after 3 months off at a low dose and the nausea arrived exactly like the first time
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
✅8❤️7🧊4
lost about 30kg on the low doses before i even got to 1, which surprised me, anyway
🤝6⚠️1
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
my 40 vial in 1.5ml gives 8mg/ml so 1.7 lands on 30 units, thats why i picked that volume
does moving my dose day by two days matter with a seven day half life
anyone compared their 4 vial dosing against the pen increments
the appetite effect faded for me around 9 months and going up fixed it for a while
the long half life flattens the trough more than people expect, i never felt a day seven dip
genuine question half life is about a week so youre roughly four to five weeks to steady state on any new dose
steady state takes weeks
genuine question my VendorInvestigate report on the Homopeptide vial came back 98.1 against a certificate saying 96.8
how long did the first 37kg take for people at the low doses
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
✅3
plateaus move
🔥1👀1🧊1
SELECT wasnt weight
back after 18 months off, do i restart at 0.25 or somewhere higher
held there too
same dose day
Channel stats, last 30 days: 38 messages from 56 members.
not the same trial
slightly off topic but what did SELECT actually measure, i see it quoted for everything
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
Channel stats, last 30 days: 88 messages from 23 members.
genuine question STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
does anyone actually run a five week step instead of four
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
🎉2📉1
slightly off topic but did the STEP 4 withdrawal arm show what i think it showed
🙏1🧪5
held at 2.5 and lost 58lb over 24 months, slower than the trials and fine by me
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
seven days ish
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
moving my dose day by a day or two never did anything noticeable for me
❤️3
is there a reason to hold at 1.7 rather than going to 2.4
✅4🎉5
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
lost about 39kg on the low doses before i even got to 1, which surprised me
i held at 7.5 for 9 months and it was the best decision i made
❤️9
update on the earlier thing going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
whats the actual licensed ceiling, i keep seeing different numbers
ok so did anyone titrate slower than four weeks a step and how did that go