same dose day
#semaglutide 2025-03-24
Monday22 messages6 participantstimes are UTC
Highlights from this day
- customs_owl — 15 months at 2.4 and the honest summary is diminishing returns after the first half 21:17
- HPLC_Hank — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 21:55
- HPLC_Hank — does anyone actually run a five week step instead of four 21:59
- first_and_last_four — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 23:09
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
i dont think the plateau is a dose problem most of the time, but i cant prove that
15 months at 2.4 and the honest summary is diminishing returns after the first half
⚠️12👍1🎉18
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
is the plateau usually appetite coming back or just the scale stopping
the long half life flattens the trough more than people expect, i never felt a day seven dip
the appetite effect faded for me around 4 months and going up fixed it for a while
held at 1 and lost 73lb over 24 months, slower than the trials and fine by me
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg😂16✅3🧪3
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
does anyone actually run a five week step instead of four
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seven days ish
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe plateau hit me at 11 weeks and moved again about a month later without a dose change
update on the earlier thing STEP 1 ran to 68 weeks. thats the one everyone half remembers
dose day is sunday for me only because thats when i remember, not because sunday matters
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
back after 5 months off, do i restart at 0.25 or somewhere higher
SELECT wasnt weight
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went too fast once
👀3🧪15🎉6
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
❤️5🙏4🎉12