not the same trial
#semaglutide 2025-04-03
Thursday50 messages11 participantstimes are UTC
Highlights from this day
- void_volume — follow up i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it, thats one data point 19:11
- orfor_watch — the plateau hit me at 34 weeks and moved again about a month later without a dose change 19:22
- monoisotopic — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 20:10
- two_ml_two — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 20:30
- two_ml_two — my PeptideMeter report on the FGP vial came back 98.1 against a certificate saying 99.4 21:12
did anyone titrate slower than four weeks a step and how did that go
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
give it four weeks
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ymmv
lost about 3kg on the low doses before i even got to 1, which surprised me
Digest for the week of 2024-09-16 has been published.
seven days ish
[edited]follow up i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it, thats one data point
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genuine question does the licensed ceiling for weight differ from the diabetes one
unrelated but the long half life flattens the trough more than people expect, i never felt a day seven dip, thats one data point
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
the plateau hit me at 34 weeks and moved again about a month later without a dose change
SELECT wasnt weight
how many weeks before you noticed anything at 1.7
restarted after 7 months off at a low dose and the nausea arrived exactly like the first time
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brand vs compounded, is there a difference people can actually feel
my 2 vial in 1ml gives 8mg/ml so 5 lands on 12 units, thats why i picked that volume
moving my dose day by a day or two never did anything noticeable for me
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how long did the first 42kg take for people at the low doses
compounded and brand felt the same to me at 1.7, which is one person and nothing more
[edited]is there a reason to hold at 1.7 rather than going to 2.4
five week steps worked better for me than four, purely on how the second week felt
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
same dose day
how long till steady state, ive read the half life is about a week
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
mine faded too
right so anyone gone from 12 straight to 15 or is that too big a jump
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
does the seven day half life mean the last two days are weaker
vials not pens here
[edited]did anyone hold at 1 longer than four weeks before going up
i held at 0.5 for 6 months and it was the best decision i made
does anyone actually run a five week step instead of four
my PeptideMeter report on the FGP vial came back 98.1 against a certificate saying 99.4
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how did people handle the jump from 1 to 1.7
held at 5 and lost 52lb over 4 months, slower than the trials and fine by me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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$240 a month for compounded against what brand costs locally is why most people here use vials
plateaus move
steady state takes weeks
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
for the archive im 10 months in at 12 and the appetite effect faded, is that a thing
is the plateau at 11 weeks normal or am i doing something wrong
is 2.4 the top or do people go past it
held at 0.5 and lost 89lb over 22 months, slower than the trials and fine by me
whats the actual licensed ceiling, i keep seeing different numbers