unrelated but i stayed on 1.7 for 11 months and never went to 2.4, appetite was already where i needed it, happy to be corrected
#semaglutide 2025-04-20
Sunday47 messages12 participantstimes are UTC
Highlights from this day
- lean_mass_lex — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 23:11
- alcohol_hits — restarted after 14 months off at a low dose and the nausea arrived exactly like the first time 23:25
- alcohol_hits — compounded and brand felt the same to me at 5, which is one person and nothing more 23:27
my VendorInvestigate report on the Homopeptide vial came back 97.4 against a certificate saying 99
dose day is sunday for me only because thats when i remember, not because sunday matters
is there a reason to hold at 1.7 rather than going to 2.4
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, i think
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
slower worked better
i held at 5 for 2 months and it was the best decision i made
half life is about a week so youre roughly four to five weeks to steady state on any new dose
same dose day
moving my dose day by a day or two never did anything noticeable for me, take that with a pinch of salt
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my 30 vial in 1ml gives 2.5mg/ml so 2.5 lands on 8 units, thats why i picked that volume, thats just me
how many weeks before you noticed anything at 7.5
$94 a month for compounded against what brand costs locally is why most people here use vials
whats the actual licensed ceiling, i keep seeing different numbers
while im here going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
seven days ish
steady state takes weeks
held at 0.25 and lost 78lb over 19 months, slower than the trials and fine by me
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
held there too
went too fast once
the plateau hit me at 24 weeks and moved again about a month later without a dose change
[edited]STEP 1 ran to 68 weeks. thats the one everyone half remembers
unrelated but changed my mind on the four week rule, i think it depends entirely on how the current dose feels, thats one data point
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is 2.4 the top or do people go past it
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
lost about 31kg on the low doses before i even got to 1, which surprised me
STEP is several trials, so saying STEP said x is usually wrong without a number after it
was SURPASS-2 the one that ran to 68 weeks or am i mixing them up
plateaus move
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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the appetite effect faded for me around 15 months and going up fixed it for a while
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did anybody find a difference between FGP and pharmacy at the same 0.25
quick one is the plateau usually appetite coming back or just the scale stopping
i dont think the plateau is a dose problem most of the time, but i cant prove that
[edited]im 18 months in at 5 and the appetite effect faded, is that a thing
restarted after 14 months off at a low dose and the nausea arrived exactly like the first time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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compounded and brand felt the same to me at 5, which is one person and nothing more
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im at 0.5 and stuck, did anyone break a plateau without going up
Digest for the week of 2024-12-02 has been published.
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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mine faded too
the long half life flattens the trough more than people expect, i never felt a day seven dip
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
five week steps worked better for me than four, purely on how the second week felt
SELECT wasnt weight
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step