my 20 vial in 0.5ml gives 2.5mg/ml so 1 lands on 20 units, thats why i picked that volume
#semaglutide 2025-05-20
Tuesday47 messages10 participantstimes are UTC
Highlights from this day
- knees_first — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 21:45
- lean_mass_lex — SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 22:10
- VialBot — Digest for the week of 2024-10-21 has been published. 22:12
- ghent_gradient — anyone gone from 5 straight to 12 or is that too big a jump 22:17
steady state takes weeks
[edited]five week steps worked better for me than four, purely on how the second week felt
not the same trial
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
lost about 11kg on the low doses before i even got to 1, which surprised me
STEP 1 ran to 68 weeks. thats the one everyone half remembers
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, take that with a pinch of salt
vials not pens here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how did people handle the jump from 1 to 1.7
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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New independent result logged — TFC, lot E-2205, purity 99.4% (Medutest).
same dose day
[edited]i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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mine faded too
the long half life flattens the trough more than people expect, i never felt a day seven dip
went too fast once
seven days ish
while im here compounded and brand felt the same to me at 1, which is one person and nothing more
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
2.4 is the ceiling
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg👀10
thats STEP 1
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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Digest for the week of 2024-10-21 has been published.
🎉4🤝10
plateaus move
does anyone actually run a five week step instead of four
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did anyone titrate slower than four weeks a step and how did that go
anyone gone from 5 straight to 12 or is that too big a jump
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i dont think the plateau is a dose problem most of the time, but i cant prove that
genuine question brand vs compounded, is there a difference people can actually feel
*Janoshik not the other one
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, still working it out
held at 2.5 and lost 60lb over 23 months, slower than the trials and fine by me
£72 a month for compounded against what brand costs locally is why most people here use vials
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
how long did the first 25kg take for people at the low doses
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i held at 1.7 for 4 months and it was the best decision i made
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
22 months at 2.4 and the honest summary is diminishing returns after the first half
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
back after 23 months off, do i restart at 0.25 or somewhere higher
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, for what its worth
update on the earlier thing whats the actual licensed ceiling, i keep seeing different numbers
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
vial units and pen clicks are different systems, mixing the two is how people end up wrong
held there too