is the plateau at 27 weeks normal or am i doing something wrong
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#semaglutide 2025-05-26
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vials not pens here
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, i could be wrong
held there too
26 months at 2.4 and the honest summary is diminishing returns after the first half
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quick one does the seven day half life mean the last two days are weaker
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
anyone gone from 10 straight to 0.25 or is that too big a jump
fridge-temps.csv
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my dose day drifted from friday to sunday, does that reset anything
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
SELECT wasnt weight
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compounded and brand felt the same to me at 0.25, which is one person and nothing more
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
im at 1 and stuck, did anyone break a plateau without going up
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
half life is about a week so youre roughly four to five weeks to steady state on any new dose
the plateau hit me at 16 weeks and moved again about a month later without a dose change
quick one does the licensed ceiling for weight differ from the diabetes one
seven days ish
slower worked better
not the same trial
did anyone hold at 1.7 longer than four weeks before going up
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i dont think the plateau is a dose problem most of the time, but i cant prove that
five week steps worked better for me than four, purely on how the second week felt, for what its worth
[edited]does moving my dose day by two days matter with a seven day half life
held at 2.5 and lost 10lb over 14 months, slower than the trials and fine by me
dose day is sunday for me only because thats when i remember, not because sunday matters
did the STEP 4 withdrawal arm show what i think it showed
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
is there a reason to hold at 1.7 rather than going to 2.4
*PeptideMeter not the other one
how did people handle the jump from 1 to 1.7
steady state takes weeks
my 5 vial in 3ml gives 4mg/ml so 0.5 lands on 12 units, thats why i picked that volume
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quick one FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, ill dig out the number
plateaus move
did anybody find a difference between QSC and pharmacy at the same 12
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how many weeks before you noticed anything at 0.25
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how long did the first 16kg take for people at the low doses