genuine question im at 0.25 and stuck, did anyone break a plateau without going up
#semaglutide 2025-06-17
Tuesday53 messages13 participantstimes are UTC
Highlights from this day
- hot_mailbox — i dont think the plateau is a dose problem most of the time, but i cant prove that 22:25
- plus_sixteen — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 22:54
- underfill_uma — restarted after 24 months off at a low dose and the nausea arrived exactly like the first time 23:33
slightly off topic but lost about 14kg on the low doses before i even got to 1, which surprised me
follow up STEP 1 ran to 68 weeks. thats the one everyone half remembers
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
my 2 vial in 3ml gives 5mg/ml so 0.25 lands on 5 units, thats why i picked that volume
vials not pens here
the plateau hit me at 18 weeks and moved again about a month later without a dose change
Channel stats, last 30 days: 46 messages from 51 members.
same dose day
not the same trial
update on the earlier thing i stayed on 1.7 for 1 months and never went to 2.4, appetite was already where i needed it
i held at 0.5 for 4 months and it was the best decision i made, not advice obviously
i dont think the plateau is a dose problem most of the time, but i cant prove that
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgthe appetite effect faded for me around 10 months and going up fixed it for a while, we shall see
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
STEP is several trials, so saying STEP said x is usually wrong without a number after it, for what its worth
vial units and pen clicks are different systems, mixing the two is how people end up wrong
£55 a month for compounded against what brand costs locally is why most people here use vials
how long till steady state, ive read the half life is about a week
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
im 9 months in at 2.4 and the appetite effect faded, is that a thing
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
*Janoshik not the other one
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
26 months at 2.4 and the honest summary is diminishing returns after the first half
SELECT wasnt weight
the long half life flattens the trough more than people expect, i never felt a day seven dip
for the archive what did SELECT actually measure, i see it quoted for everything
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
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five week steps worked better for me than four, purely on how the second week felt
does the seven day half life mean the last two days are weaker
mine faded too
did the STEP 4 withdrawal arm show what i think it showed
plateaus move
dose day is sunday for me only because thats when i remember, not because sunday matters
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
seven days ish
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
thats STEP 1
held there too
compounded and brand felt the same to me at 2.5, which is one person and nothing more
held at 5 and lost 104lb over 4 months, slower than the trials and fine by me
did anyone titrate slower than four weeks a step and how did that go
is there a reason to hold at 1.7 rather than going to 2.4
steady state takes weeks
restarted after 24 months off at a low dose and the nausea arrived exactly like the first time
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how did people handle the jump from 1 to 1.7
how long did the first 21kg take for people at the low doses
anyone gone from 7.5 straight to 5 or is that too big a jump
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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my Medutest report on the WXT vial came back 99.4 against a certificate saying 96.8