held at 2 and lost 13lb over 5 months, slower than the trials and fine by me
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#semaglutide 2025-07-24
Thursday43 messages9 participantstimes are UTC
Highlights from this day
- identity_shift — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 16:09
- identity_shift — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, for what its worth 16:42
- madrid_mg — follow up back after 12 months off, do i restart at 0.25 or somewhere higher 18:24
STEP 1 ran to 68 weeks. thats the one everyone half remembers
[edited]my 5 vial in 2ml gives 5mg/ml so 0.25 lands on 12 units, thats why i picked that volume
i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it
vials not pens here
anyone gone from 2.4 straight to 0.25 or is that too big a jump
mine faded too
compounded and brand felt the same to me at 0.5, which is one person and nothing more
while im here did anybody find a difference between CPC and pharmacy at the same 0.25
does the seven day half life mean the last two days are weaker
went too fast once
plateaus move
i dont think the plateau is a dose problem most of the time, but i cant prove that
anyone compared their 2.5 vial dosing against the pen increments
did the STEP 4 withdrawal arm show what i think it showed
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how long till steady state, ive read the half life is about a week
is the plateau usually appetite coming back or just the scale stopping
moving my dose day by a day or two never did anything noticeable for me
the long half life flattens the trough more than people expect, i never felt a day seven dip
Testing queue: 7 submissions open, 82 awaiting dispatch.
not the same trial
is there a reason to hold at 1.7 rather than going to 2.4
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
the appetite effect faded for me around 5 months and going up fixed it for a while
[edited]going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, for what its worth
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is 2.4 the top or do people go past it
sorry to jump in FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
five week steps worked better for me than four, purely on how the second week felt
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25 months at 2.4 and the honest summary is diminishing returns after the first half
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgRecon calculator: 15mg in 2.5ml = 10mg/ml.
steady state takes weeks
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held there too
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coming back to this brand vs compounded, is there a difference people can actually feel
i held at 1 for 2 months and it was the best decision i made
Assay note: MKM lot E-2205 reported at 98.6% of label content.
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follow up back after 12 months off, do i restart at 0.25 or somewhere higher
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did anyone hold at 7.5 longer than four weeks before going up
does anyone actually run a five week step instead of four
my dose day drifted from friday to sunday, does that reset anything
my VendorInvestigate report on the SGN vial came back 99 against a certificate saying 96.8