the plateau hit me at 13 weeks and moved again about a month later without a dose change
#semaglutide 2025-08-11
Monday26 messages8 participantstimes are UTC
Highlights from this day
how long did the first 8kg take for people at the low doses
five week steps worked better for me than four, purely on how the second week felt, thats just me
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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thats STEP 1
unrelated but FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
slower worked better
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mine faded too
coming back to this whats the actual licensed ceiling, i keep seeing different numbers
Inter-lab diff for lot F-1330: 98.6% vs 98.1%. Within expected range.
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not the same trial
how many weeks before you noticed anything at 15
[edited]i held at 0.25 for 9 months and it was the best decision i made
moving my dose day by a day or two never did anything noticeable for me
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
coming back to this anyone compared their 8 vial dosing against the pen increments
how did people handle the jump from 1 to 1.7
SELECT wasnt weight
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was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
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the long half life flattens the trough more than people expect, i never felt a day seven dip
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
my 40 vial in 5ml gives 8mg/ml so 15 lands on 15 units, thats why i picked that volume
for the archive steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
im at 0.5 and stuck, did anyone break a plateau without going up
vial units and pen clicks are different systems, mixing the two is how people end up wrong
STEP 1 ran to 68 weeks. thats the one everyone half remembers
$185 a month for compounded against what brand costs locally is why most people here use vials
what did SELECT actually measure, i see it quoted for everything