£38 a month for compounded against what brand costs locally is why most people here use vials
#semaglutide 2025-09-14
Sunday55 messages13 participantstimes are UTC
Highlights from this day
- escalation_anxiety — if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 12:23
- VialBot — Assay note: QSC lot SG-1177 reported at 98.6% of label content. 16:36
- per_mg_pete — how many weeks before you noticed anything at 7.5 18:25
- VialBot — Channel stats, last 30 days: 86 messages from 28 members. 18:28
held there too
does moving my dose day by two days matter with a seven day half life
2.4 is the ceiling
update on the earlier thing brand vs compounded, is there a difference people can actually feel
the long half life flattens the trough more than people expect, i never felt a day seven dip
thats STEP 1
fridge-thermometer.png
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if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming back to this STEP is several trials, so saying STEP said x is usually wrong without a number after it, ymmv
compounded and brand felt the same to me at 2.4, which is one person and nothing more
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went too fast once
seven days ish
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vials not pens here
mine faded too
ok so went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
same dose day
i held at 10 for 9 months and it was the best decision i made
im 17 months in at 1.7 and the appetite effect faded, is that a thing
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the appetite effect faded for me around 2 months and going up fixed it for a while
whats the actual licensed ceiling, i keep seeing different numbers
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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Channel stats, last 30 days: 19 messages from 52 members.
held at 0.25 and lost 95lb over 7 months, slower than the trials and fine by me
give it four weeks
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plateaus move
my VendorInvestigate report on the SSA vial came back 98.6 against a certificate saying 99.2
did anyone titrate slower than four weeks a step and how did that go
STEP 1 ran to 68 weeks. thats the one everyone half remembers
i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it
did anyone hold at 2.4 longer than four weeks before going up
does the licensed ceiling for weight differ from the diabetes one
SELECT wasnt weight
steady state takes weeks
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my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
is there a reason to hold at 1.7 rather than going to 2.4
slower worked better
vial units and pen clicks are different systems, mixing the two is how people end up wrong
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, ymmv
[edited]is the plateau usually appetite coming back or just the scale stopping
Assay note: QSC lot SG-1177 reported at 98.6% of label content.
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coming back to this 17 months at 2.4 and the honest summary is diminishing returns after the first half
not the same trial
peptidemeter-summary-sg-1177.pdf
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the appetite effect faded for me around 5 months and going up fixed it for a while
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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does anyone actually run a five week step instead of four
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steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
*Janoshik not the other one
how many weeks before you noticed anything at 7.5
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🙏18📈7⚠️10
Channel stats, last 30 days: 86 messages from 28 members.
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im at 12 and stuck, did anyone break a plateau without going up
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
moving my dose day by a day or two never did anything noticeable for me
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
my 15 vial in 2ml gives 2.5mg/ml so 2 lands on 20 units, thats why i picked that volume