slightly off topic but went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
#semaglutide 2025-10-26
Sunday41 messages10 participantstimes are UTC
Highlights from this day
- juno_joins — my VendorInvestigate report on the Homopeptide vial came back 97.4 against a certificate saying 99.2 22:26
- deadspace — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down 22:36
- oasis_ola — my 40 vial in 3ml gives 10mg/ml so 0.5 lands on 8 units, thats why i picked that volume 22:49
- u100_pat — the long half life flattens the trough more than people expect, i never felt a day seven dip 23:04
- gip_glp_gil — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 23:33
sorry to jump in steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
my VendorInvestigate report on the Homopeptide vial came back 97.4 against a certificate saying 99.2
2.4 is the ceiling
does moving my dose day by two days matter with a seven day half life
vial units and pen clicks are different systems, mixing the two is how people end up wrong
dose day is sunday for me only because thats when i remember, not because sunday matters
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
vials not pens here
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how long till steady state, ive read the half life is about a week
the appetite effect faded for me around 15 months and going up fixed it for a while
coming back to this my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
five week steps worked better for me than four, purely on how the second week felt
while im here whats the actual licensed ceiling, i keep seeing different numbers
my 40 vial in 3ml gives 10mg/ml so 0.5 lands on 8 units, thats why i picked that volume
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwent too fast once
SELECT wasnt weight
give it four weeks
mine faded too
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
Batch lookup B-0329: 9 independent reports on file, earliest 2025-01-08.
did anybody find a difference between SWB and pharmacy at the same 1.7
the long half life flattens the trough more than people expect, i never felt a day seven dip
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same dose day
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seven days ish
slower worked better
moving my dose day by a day or two never did anything noticeable for me
how did people handle the jump from 1 to 1.7
[edited]did the STEP 4 withdrawal arm show what i think it showed
restarted after 15 months off at a low dose and the nausea arrived exactly like the first time, i think
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
not the same trial
the plateau hit me at 10 weeks and moved again about a month later without a dose change, ask me again in a month
held at 2.5 and lost 74lb over 24 months, slower than the trials and fine by me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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Recon calculator: 20mg in 2ml = 5mg/ml.
i held at 12 for 2 months and it was the best decision i made
my dose day drifted from friday to sunday, does that reset anything
plateaus move
what did SELECT actually measure, i see it quoted for everything