if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
#semaglutide 2025-10-28
Tuesday60 messages14 participantstimes are UTC
Highlights from this day
- egfr_ed — half life is about a week so youre roughly four to five weeks to steady state on any new dose 22:05
- surpass_two — did the STEP 4 withdrawal arm show what i think it showed 22:07
- ruo_only — was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up compounded and brand felt the same to me at 2.4, which is one person and nothing more 23:33
- cagri_curious — vial units and pen clicks are different systems, mixing the two is how people end up wrong 23:41
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
slower worked better
vials not pens here
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does the licensed ceiling for weight differ from the diabetes one
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
STEP is several trials, so saying STEP said x is usually wrong without a number after it
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
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did the STEP 4 withdrawal arm show what i think it showed
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my dose day drifted from friday to sunday, does that reset anything
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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went too fast once
brand vs compounded, is there a difference people can actually feel
give it four weeks
how long did the first 29kg take for people at the low doses
unrelated but i stayed on 1.7 for 21 months and never went to 2.4, appetite was already where i needed it
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
SELECT wasnt weight
compounded and brand felt the same to me at 1.7, which is one person and nothing more
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plateaus move
ok so 26 months at 2.4 and the honest summary is diminishing returns after the first half
im 7 months in at 0.5 and the appetite effect faded, is that a thing
Recon calculator: 2mg in 5ml = 2.5mg/ml.
Purity check: no report on file for lot B-0114. Nothing logged either way.
same dose day
what did SELECT actually measure, i see it quoted for everything
for the archive back after 15 months off, do i restart at 0.25 or somewhere higher
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgheld at 5 and lost 101lb over 19 months, slower than the trials and fine by me
my 2 vial in 2ml gives 4mg/ml so 2.5 lands on 30 units, thats why i picked that volume
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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does anyone actually run a five week step instead of four
not the same trial
seven days ish
mine faded too
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thats STEP 1
steady state takes weeks
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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2.4 is the ceiling
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
the appetite effect faded for me around 23 months and going up fixed it for a while
Recon calculator: 2mg in 1ml = 10mg/ml.
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£38 a month for compounded against what brand costs locally is why most people here use vials, not advice obviously
moving my dose day by a day or two never did anything noticeable for me
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
is there a reason to hold at 1.7 rather than going to 2.4
i dont think the plateau is a dose problem most of the time, but i cant prove that
dose day is sunday for me only because thats when i remember, not because sunday matters, still working it out
lost about 25kg on the low doses before i even got to 1, which surprised me
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
is 2.4 the top or do people go past it
five week steps worked better for me than four, purely on how the second week felt
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does the seven day half life mean the last two days are weaker
the plateau hit me at 34 weeks and moved again about a month later without a dose change
Recon calculator: 5mg in 5ml = 5mg/ml.
was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
compounded and brand felt the same to me at 2.4, which is one person and nothing more
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgfollow up anyone gone from 12 straight to 0.5 or is that too big a jump
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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New independent result logged — SWB, lot G-0641, purity 99.2% (Janoshik).
i held at 2.5 for 6 months and it was the best decision i made, ask me again in a month