im 11 months in at 10 and the appetite effect faded, is that a thing
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#semaglutide 2025-11-06
Thursday35 messages8 participantstimes are UTC
Highlights from this day
- site_itch — the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing i held at 5 for 4 months and it was the best decision i made 22:03
- monoisotopic — i held at 7.5 for 4 months and it was the best decision i made 22:55
- lena_lots — for the archive my 2 vial in 3ml gives 5mg/ml so 12 lands on 12 units, thats why i picked that volume 23:04
restarted after 5 months off at a low dose and the nausea arrived exactly like the first time
what did SELECT actually measure, i see it quoted for everything
the long half life flattens the trough more than people expect, i never felt a day seven dip, not advice obviously
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the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
i held at 5 for 4 months and it was the best decision i made
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how long till steady state, ive read the half life is about a week
dose day is sunday for me only because thats when i remember, not because sunday matters
plateaus move
give it four weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held at 10 and lost 84lb over 6 months, slower than the trials and fine by me
moving my dose day by a day or two never did anything noticeable for me
my VendorInvestigate report on the HJ vial came back 99.4 against a certificate saying 99
does the licensed ceiling for weight differ from the diabetes one
is 2.4 the top or do people go past it
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
whats the actual licensed ceiling, i keep seeing different numbers
[edited]STEP 1 ran to 68 weeks. thats the one everyone half remembers
compounded and brand felt the same to me at 7.5, which is one person and nothing more
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
thats STEP 1
dose day is sunday for me only because thats when i remember, not because sunday matters
18 months at 2.4 and the honest summary is diminishing returns after the first half
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
i held at 7.5 for 4 months and it was the best decision i made
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgseven days ish
for the archive my 2 vial in 3ml gives 5mg/ml so 12 lands on 12 units, thats why i picked that volume
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how many weeks before you noticed anything at 1.7
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i stayed on 1.7 for 8 months and never went to 2.4, appetite was already where i needed it
did anybody find a difference between FGP and pharmacy at the same 1
brand vs compounded, is there a difference people can actually feel
is the plateau at 23 weeks normal or am i doing something wrong
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not the same trial
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quick one is there a reason to hold at 1.7 rather than going to 2.4
steady state takes weeks
vials not pens here