how did people handle the jump from 1 to 1.7
#semaglutide 2025-11-10
Monday29 messages7 participantstimes are UTC
Highlights from this day
- no_escrow_nate — STEP 1 ran to 68 weeks. thats the one everyone half remembers 19:59
- surpass_two — STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 20:12
- half_life_hal — coming back to this 17 months at 2.4 and the honest summary is diminishing returns after the first half 20:25
- half_life_hal — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 21:47
sorry to jump in SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ymmv
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
five week steps worked better for me than four, purely on how the second week felt
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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compounded and brand felt the same to me at 10, which is one person and nothing more
how long did the first 19kg take for people at the low doses
coming back to this 17 months at 2.4 and the honest summary is diminishing returns after the first half
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggoing slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
my 20 vial in 2ml gives 2.5mg/ml so 7.5 lands on 8 units, thats why i picked that volume
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mine faded too
[edited]give it four weeks
did anyone titrate slower than four weeks a step and how did that go
follow up does the licensed ceiling for weight differ from the diabetes one
coming back to this the plateau hit me at 33 weeks and moved again about a month later without a dose change
moving my dose day by a day or two never did anything noticeable for me
thats STEP 1
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
not the same trial
STEP is several trials, so saying STEP said x is usually wrong without a number after it
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
how long till steady state, ive read the half life is about a week
does the seven day half life mean the last two days are weaker
slightly off topic but whats the actual licensed ceiling, i keep seeing different numbers
*PeptideMeter not the other one
steady state takes weeks
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slower worked better
coa-d-0718.pdf
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