#semaglutide 2025-11-20

Thursday33 messages8 participantstimes are UTC

Highlights from this day

assay_not_purity — anyone gone from 1 straight to 2.5 or is that too big a jump 11:50
ms_ms_mira — STEP is several trials, so saying STEP said x is usually wrong without a number after it 12:44
lipase_lore — licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 15:23

lipase_lore 10:53

i stayed on 1.7 for 12 months and never went to 2.4, appetite was already where i needed it

while im here the long half life flattens the trough more than people expect, i never felt a day seven dip

blank_runlab11:00

genuine question did the STEP 4 withdrawal arm show what i think it showed

blank_runlab11:15

brand vs compounded, is there a difference people can actually feel

lipase_lore 11:16

thats STEP 1

lipase_lore 11:43

ok so went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

month_six_me 11:45

STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

slightly off topic but i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, ymmv

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, thats one data point

assay_not_puritylab11:50

anyone gone from 1 straight to 2.5 or is that too big a jump

🔥10

unrelated but my PeptideMeter report on the SWB vial came back 99 against a certificate saying 98.1

half life is about a week so youre roughly four to five weeks to steady state on any new dose, not advice obviously

month_six_me 11:53

i dont think the plateau is a dose problem most of the time, but i cant prove that

assay_not_puritylab12:17

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial

lipase_lore while im here the long half life flattens the trough more than people expect, i never…

month_six_me 12:33

$185 a month for compounded against what brand costs locally is why most people here use vials, happy to be corrected

what did SELECT actually measure, i see it quoted for everything

not the same trial

ms_ms_miralab12:42

went too fast once

STEP is several trials, so saying STEP said x is usually wrong without a number after it

👍7🧪6

does the seven day half life mean the last two days are weaker

blank_runlab12:47

moving my dose day by a day or two never did anything noticeable for me, n of 1 obviously
the appetite effect faded for me around 15 months and going up fixed it for a while

*Medutest not the other one

taper_tess 12:53

my plateau was the scale stopping while appetite stayed suppressed, which is a different problem

taper_tess 13:13

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, i have it written down somewhere

VialBotbot13:14

Reminder for mg_per_ml: dose day is today. Set 2 days ago.

mg_per_ml 13:16

update on the earlier thing lost about 38kg on the low doses before i even got to 1, which surprised me

mg_per_ml 14:47

im at 5 and stuck, did anyone break a plateau without going up

🙏6