#semaglutide 2025-11-27

for the archive half life is about a week so youre roughly four to five weeks to steady state on any new dose

ok so five week steps worked better for me than four, purely on how the second week felt, i have it written down somewhere

my 2 vial in 3ml gives 4mg/ml so 12 lands on 25 units, thats why i picked that volume

how did people handle the jump from 1 to 1.7

steady state takes weeks

lost about 19kg on the low doses before i even got to 1, which surprised me

right so i dont think the plateau is a dose problem most of the time, but i cant prove that

SELECT wasnt weight

seven days ish

£55 a month for compounded against what brand costs locally is why most people here use vials

compounded and brand felt the same to me at 15, which is one person and nothing more

for the archive STEP 1 ran to 68 weeks. thats the one everyone half remembers

while im here moving my dose day by a day or two never did anything noticeable for me

the appetite effect faded for me around 9 months and going up fixed it for a while

held there too

23 months at 2.4 and the honest summary is diminishing returns after the first half

SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, ill dig out the number

did anybody find a difference between CPC and pharmacy at the same 1

give it four weeks

same dose day

FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

genuine question did anyone titrate slower than four weeks a step and how did that go

whats the actual licensed ceiling, i keep seeing different numbers

my dose day drifted from friday to sunday, does that reset anything

is the plateau at 15 weeks normal or am i doing something wrong

vial units and pen clicks are different systems, mixing the two is how people end up wrong

dose day is sunday for me only because thats when i remember, not because sunday matters

anyone gone from 15 straight to 1 or is that too big a jump

STEP is several trials, so saying STEP said x is usually wrong without a number after it

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

sorry to jump in how long did the first 16kg take for people at the low doses

mine faded too

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changed my mind on the four week rule, i think it depends entirely on how the current dose feels

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule

did anyone hold at 0.25 longer than four weeks before going up

does moving my dose day by two days matter with a seven day half life

plateaus move

went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down

is there a reason to hold at 1.7 rather than going to 2.4